Overview |
"Coordinated study for therapy and the neurobiological basis' of addiction,Tübingen"The first part of the study will address the addictive and rewarding effects glutamate/N-methyl-D-aspartate receptor antagonists and compare these to the effects of dopamine-agonists and morphin. In consequence, pharmacological approaches for intervention will be tested.
Center of the second part is the question, whether plastic processes (sensitization and tolerance) leading to dependence and addiction, are influenced by NMDA receptor antagonists. Rat studies will elucidate, which behaviour shows sensitization and which tolerance on the repeated application of a drug. In the next step these processes of neuronal plasticity shall be blocked by NMDA receptor antagonists, thus possibly decreasing the occurance of "craving" and withdrawal symptoms. These experiments are directly connected to understanding the mechanism of new potential anticraving drugs for alcohol-addiction.
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Document last modified April, 9th 1997 Ulrich Kronthaler, ulrich.kronthaler@student.uni-tuebingen.de(ulrich.kronthaler@student.uni-tuebingen.de) |